Learn how Calocurb helps your body regulate cravings through gentle, natural hormone activation without shots and without risk of rebound if you go off of it.
A Natural Way to Curb Cravings: Meet Calocurb® CLINICAL
If you’ve been hearing about Ozempic®, Wegovy®, or Mounjaro® lately, you’re not alone. These GLP-1 medications are known for reducing appetite, but they come with a prescription, high cost, and potential side effects.
What if you could activate your body’s own appetite-control hormones without drugs or injections?
That’s what Calocurb® CLINICAL was created to do.
A Breakthrough from New Zealand: 15 Years and $30 Million of Research
Calocurb’s key ingredient, Amarasate®, was developed by Plant & Food Research, New Zealand’s largest government-owned research institute. After 15 years and $30 million in government funding, researchers discovered a natural way to prompt the gut to release hormones that tell the brain you’ve had enough to eat.
The result is a patented bitter-hops extract that supports healthy appetite control in a completely natural way. Released in 2024, Amarasate® powers Calocurb®, a next-generation supplement designed to help manage cravings and hunger without drugs or stimulants.
How It Works
When taken on an empty stomach, Calocurb’s delayed-release capsule moves through the stomach and opens in the small intestine. There, Amarasate® activates bitter taste receptors in the gut wall. This signal causes the release of the body’s own appetite-regulating hormones — GLP-1, CCK, and PYY — which tell the brain to reduce hunger and increase feelings of fullness, often within an hour.
What Research Shows
Natural GLP-1 activation – about a twofold increase in GLP-1 levels (2)
Fewer cravings – women experienced up to 40 % fewer food cravings vs placebo (3)
Less hunger – roughly 30 % lower hunger ratings during fasting (1)
Lower calorie intake – men ate about 18 % fewer calories at the next meal (2)
Fast, lasting effect – begins in about one hour and lasts up to six hours
Findings from controlled clinical trials in healthy adults; individual results may vary.
Calocurb® CLINICAL is a higher dose than the publicly available version and is intended to be used under the care of a holistic practitioner like Dr. Rehl.
How Calocurb Differs from GLP-1 Drugs
Medications such as Ozempic®, Mounjaro®, Victoza®, and Trulicity® directly activate GLP-1 receptors. They are effective, but they override the body’s natural rhythm, and appetite usually returns when the medication is stopped.
Calocurb works differently. Instead of replacing GLP-1, it gently stimulates the body to release it naturally, along with CCK and PYY. It supports the body’s own physiology, offering a natural option for appetite control and ongoing maintenance.
| Aspect | GLP-1 Drugs (e.g., Ozempic, Mounjaro) | Calocurb (Amarasate®) |
|---|---|---|
| Type | Synthetic hormone (drug) | Natural bitter-hops extract (nutraceutical) |
| Mechanism | Directly activates GLP-1 receptor | Stimulates gut cells to release GLP-1, CCK, PYY |
| Duration | Long-acting (days) | Short-acting (~6 hours) |
| Delivery | Injection or oral prescription | Oral capsule (OTC) |
| Purpose | Treats obesity/diabetes | Supports appetite control and weight maintenance |
Clean, Natural Formulation
- 100 % plant-based and vegan
- Gluten-free, non-GMO, glyphosate-free, and Kosher
- No caffeine, stimulants, or artificial additives
- Patented delayed-release capsule for targeted intestinal delivery
- Produced in a GMP-certified facility using CO₂ supercritical extraction (no harsh solvents)
- Fully traceable from New Zealand hops farms to final capsule
Clinical References
- Nutrients (2019): New Zealand Bitter Hops Extract Reduces Hunger During a 24-h Water-Only Fast — PubMed | Full Text
- Am J Clin Nutr (2022): An extract of hops (Humulus lupulus L.) modulates gut peptide hormone secretion and reduces energy intake in healthy-weight men — PubMed | ScienceDirect
- Obesity Pillars (2024): Gastrointestinal delivery of bitter hops extract reduces appetite and food cravings in healthy adult women undergoing acute fasting — PubMed
The Takeaway
Calocurb doesn’t promise weight loss; it supports the behaviors that make it possible. By calming hunger and reducing cravings, it helps you stay consistent with healthy eating and mindful portions. If you’re looking for the appetite benefits associated with GLP-1 activation but want a natural, research-backed alternative, Calocurb® may be a smart place to start.
Ask about Calocurb at your next visit or contact our office to learn more. 925-330-3326